>>321
äžéšæç²
10,000çµãè¶
ããåçå
ã®çžŠæç 究ãããäŸåçã®åå ã®çŽåå以äžã¯éºäŒãåå ã§ããããšãããã£ãŠãããããã¯ç·å¥³å
±éãšãããŠããŸãããã®ä»ã«ãã¢ã«ã³ãŒã«äŸåçã¯ãã³ãã³ãªã©ä»ã®è¬ç©äŸåã»ä¹±çšãšå䜵ããããšãå€ãã®ã§ãããå
±éã®éºäŒå åã®ããããšãå ±åãããŠããŸãã
2. ã¢ã«ã³ãŒã«ä»£è¬é
µçŽ éºäŒåãšäŸåçã®é¢ä¿
æ°å€ãã®éºäŒåãåå ã®åè£ãšããŠæ€èšãããŸããããã¢ã«ã³ãŒã«ã代è¬ããé
µçŽ ã®éºäŒå以å€ã«æ±ºå®çãªåè£ã¯èŠã€ãã£ãŠããŸããã
ã¢ã«ã³ãŒã«ã代è¬ããé
µçŽ ã®éºäŒåã«ã¯ããã€ãã®ã¿ã€ãïŒéºäŒåå€åïŒããããäŸåçã«é¢ä¿ããŸããèèã§ã¯ãã¢ã«ã³ãŒã«ãã¢ã»ãã¢ã«ãããã«å解ããã¢ã«ã³ãŒã«è±æ°ŽçŽ é
µçŽ (ADH1B)ãšãã¢ã«ã³ãŒã«ã代è¬ãããŠã§ããæ害ãªã¢ã»ãã¢ã«ããããç¡æ¯ãªé
¢é
žã«å解ããã¢ã«ãããè±æ°ŽçŽ é
µçŽ (ALDH2)ãã¢ã«ã³ãŒã«ä»£è¬ã®äžå¿çãªåœ¹å²ãæãããŸããããã®äž¡æ¹ã®éºäŒåã«å€åãååšããŸãã
ADH1Bã«ã¯His48Argå€åãããã48çªç®ã®ã¢ããé
žããã¹ããžã³(His)ã®äººãšã¢ã«ã®ãã³(Arg)ã®äººãããŸããHisã®äººã¯æ±æŽäººã«å€ããã¢ã«ã³ãŒã«ãå解ããé床ãéåžžã«éããšããç¹åŸŽããããŸãã