æ¯èŒçæåèŠãããŠãã説ãšããŠæ¬¡ã®ããšãèšãããŠããŸãã
ãã¡ã€ã¶ãŒç€Ÿè£œã¯ã¯ãã³ã®äž»æåã¯mRNAã§ããmRNAã¯èãèèªã®èã«å ãŸããŠããŸãïŒãªããœãŒã ãšèšããŸãïŒããªããœãŒã ãå®å®çã«ä¿ã€ããã«ããªãšãã¬ã³ã°ãªã³ãŒã«ïŒPEGïŒãã¯ã¯ãã³æ¶²ã«ã¯å«ãŸããŠããŸããPEGã¯ãã¯ã¯ãã³ã人éã®äœã«å ¥ã£ããšããªããœãŒã ã现èå ã«åã蟌ãŸããã®ã«ã圹ç«ã€ãšãããŸãããã®ããmRNAåã®ã¯ã¯ãã³ã«PEGãæ¬ ãããŸããã
mRNAãšèèªèãã¢ã¬ã«ã®ãŒã®åå ç©è³ªã«ãªãå¯èœæ§ã¯ãã¡ããåŠå®ã§ããŸããããã©ã¡ããçäœå ã«æ®éã«ååšãããã®ã§ãããããããPEGãã¢ããã£ã©ãã·ãŒã®åå ç©è³ªãããããªãããšãã話ã«ãªããŸããã
PEGã¯å»è¬åã§ã¯ç·©äžå€ïŒç©ãããªäžå€ïŒã«äœ¿ãããŠããŸããå»è¬å以å€ã§å§åçã«å€ã䜿ãããŠããã®ã¯å粧åã§ããéã€ãªã³æ§çé¢æŽ»æ§å€ãšããŠä¹³æ¶²ã«ããããå«ãŸããŠãããšãããŸãã
ãšãªããšãå粧åãå€ã䜿ã女æ§ã¯æ¢ã«PEGã«å¯ŸããŠæäœãããŠããã®ã§ã¯ãªããããã®ãã女æ§ã«mRNAåã¯ã¯ãã³æ¥çš®åŸã®ã¢ããã£ã©ãã·ãŒãå€ãã®ã§ã¯ãªããããšãã仮説ãåºãŠãããšããããã§ãã
ãã®çåœã®çšã¯ããŠããããã¡ã€ã¶ãŒç€Ÿè£œã®æ°åã³ãããŠã€ã«ã¹ã¯ã¯ãã³æ¥çš®åŸã®ã¢ããã£ã©ãã·ãŒãæ¥æ¬ã§ã¯æ¬§ç±³ã®å ±åãããå€ãããšã泚ç®ãããŠããŸãã
çŸåšãæ¥æ¬ã§ã¯å»çåŸäºè ã«ãã¡ã€ã¶ãŒç€Ÿè£œã¯ã¯ãã³ãæ¥çš®ãããŠããŸããæ¥çš®ãåããå»çåŸäºè çŽ17äžäººã®ãã¡7人ã«ã¢ããã£ã©ãã·ãŒãçºçãããšããã®ã§ãããã®ã»ãšãã©ã女æ§ã§ããã
mRNAåã¯ã¯ãã³æ¥çš®åŸã®å¯åå¿ã«ã€ããŠã¯ããã®ããã°ã§çŽ¹ä»ããããšããããŸãïŒ2021/2/15ïŒããã¥ãŒã€ã³ã°ã©ã³ãå»åŠèªïŒNEJMïŒã®å ±åã§ã¯ãã¡ã€ã¶ãŒç€Ÿè£œã¯ã¯ãã³990äžäœãã®æ¥çš®ã§ã¯47åã®ã¢ããã£ã©ãã·ãŒãããªãã¡22äž5ååã«1åã®ã¢ããã£ã©ãã·ãŒã®é »åºŠã§ããã
ãšãããæ¥æ¬ã®å»çåŸäºè ã§ã¯ã2äž7ååã«1åã®ã¢ããã£ã©ãã·ãŒã ãšããã®ã§ãã確ãã«NEJMã®å ±åããé »åºŠã10åè¿ãå€ãããšã«ãªããŸãã
ãã¡ã€ã¶ãŒç€Ÿè£œã¯ã¯ãã³ã®äž»æåã¯mRNAã§ããmRNAã¯èãèèªã®èã«å ãŸããŠããŸãïŒãªããœãŒã ãšèšããŸãïŒããªããœãŒã ãå®å®çã«ä¿ã€ããã«ããªãšãã¬ã³ã°ãªã³ãŒã«ïŒPEGïŒãã¯ã¯ãã³æ¶²ã«ã¯å«ãŸããŠããŸããPEGã¯ãã¯ã¯ãã³ã人éã®äœã«å ¥ã£ããšããªããœãŒã ã现èå ã«åã蟌ãŸããã®ã«ã圹ç«ã€ãšãããŸãããã®ããmRNAåã®ã¯ã¯ãã³ã«PEGãæ¬ ãããŸããã
mRNAãšèèªèãã¢ã¬ã«ã®ãŒã®åå ç©è³ªã«ãªãå¯èœæ§ã¯ãã¡ããåŠå®ã§ããŸããããã©ã¡ããçäœå ã«æ®éã«ååšãããã®ã§ãããããããPEGãã¢ããã£ã©ãã·ãŒã®åå ç©è³ªãããããªãããšãã話ã«ãªããŸããã
PEGã¯å»è¬åã§ã¯ç·©äžå€ïŒç©ãããªäžå€ïŒã«äœ¿ãããŠããŸããå»è¬å以å€ã§å§åçã«å€ã䜿ãããŠããã®ã¯å粧åã§ããéã€ãªã³æ§çé¢æŽ»æ§å€ãšããŠä¹³æ¶²ã«ããããå«ãŸããŠãããšãããŸãã
ãšãªããšãå粧åãå€ã䜿ã女æ§ã¯æ¢ã«PEGã«å¯ŸããŠæäœãããŠããã®ã§ã¯ãªããããã®ãã女æ§ã«mRNAåã¯ã¯ãã³æ¥çš®åŸã®ã¢ããã£ã©ãã·ãŒãå€ãã®ã§ã¯ãªããããšãã仮説ãåºãŠãããšããããã§ãã
ãã®çåœã®çšã¯ããŠããããã¡ã€ã¶ãŒç€Ÿè£œã®æ°åã³ãããŠã€ã«ã¹ã¯ã¯ãã³æ¥çš®åŸã®ã¢ããã£ã©ãã·ãŒãæ¥æ¬ã§ã¯æ¬§ç±³ã®å ±åãããå€ãããšã泚ç®ãããŠããŸãã
çŸåšãæ¥æ¬ã§ã¯å»çåŸäºè ã«ãã¡ã€ã¶ãŒç€Ÿè£œã¯ã¯ãã³ãæ¥çš®ãããŠããŸããæ¥çš®ãåããå»çåŸäºè çŽ17äžäººã®ãã¡7人ã«ã¢ããã£ã©ãã·ãŒãçºçãããšããã®ã§ãããã®ã»ãšãã©ã女æ§ã§ããã
mRNAåã¯ã¯ãã³æ¥çš®åŸã®å¯åå¿ã«ã€ããŠã¯ããã®ããã°ã§çŽ¹ä»ããããšããããŸãïŒ2021/2/15ïŒããã¥ãŒã€ã³ã°ã©ã³ãå»åŠèªïŒNEJMïŒã®å ±åã§ã¯ãã¡ã€ã¶ãŒç€Ÿè£œã¯ã¯ãã³990äžäœãã®æ¥çš®ã§ã¯47åã®ã¢ããã£ã©ãã·ãŒãããªãã¡22äž5ååã«1åã®ã¢ããã£ã©ãã·ãŒã®é »åºŠã§ããã
ãšãããæ¥æ¬ã®å»çåŸäºè ã§ã¯ã2äž7ååã«1åã®ã¢ããã£ã©ãã·ãŒã ãšããã®ã§ãã確ãã«NEJMã®å ±åããé »åºŠã10åè¿ãå€ãããšã«ãªããŸãã