>>216
以äžãã³ãã
ADEã¯ãèªç¶ææãã¯ã¯ãã³ã«ãã£ãŠäœå
ã«äœãããäžåèœã®ãªãæäœãããŠã€ã«ã¹ã人ã®çŽ°èã«å
¥ãããã®ãå©ãããŠã€ã«ã¹ã®ææã«ããçç¶ãæªåãããŠããŸãçŸè±¡ã§ããããã¯ãã³ã°ç±ã¯ã¯ãã³çã§å ±åãããŸãã1)ããŸãå
ç«è€åäœçãæ°éã§åŒ·ãççãåŒãèµ·ããããšããããŸã(ã¯ã¯ãã³é¢é£å¢åŒ·åŒåžåšçŸæ£ Vaccine-associated enhanced respiratory disease;VAERDïŒã
ã¯ã¯ãã³éçºã§ã¯ãADEãVAERDãèµ·ãããªãããã«ãé«ãäžåèœãããæäœãäœããããããŠTh1现èåªäœã®å
ç«åå¿ãèªå°ããã¯ã¯ãã³ã®éçºã倧åãšãããŸãããã¡ã€ã¶ãŒã»ããªã³ããã¯ç€Ÿã¯ã¯ãã³ãã¢ãã«ã瀟ã¯ã¯ãã³ããªãã¯ã¹ãã©ãŒãã»ã¢ã¹ãã©ãŒãã«ç€Ÿã¯ã¯ãã³å
šãŠã«ãããŠãèªå°ãããæäœã¯é«ãäžåèœãæã€ããšãåãã£ãŠããŸãããŸããTh1åªäœã®å
ç«ãèªå°ãããããšãåãã£ãŠããŸãã第2/3çžã®èšåºè©Šéšã§ã¯ADEãèµ·ããã被éšè
ã¯ããŸããã§ãã2-3)ãéçæ£è
ãæ®ã©ãã¯ã¯ãã³çŸ€ã§ã¯ãªããã©ã»ã矀ã§çºçããŠããŸããVAERDã¯mRNAã¯ã¯ãã³æ¥çš®åŸã®åç©å®éšã§ã芳å¯ãããŠããŸãã4-5)ããããã£ãããšããã¯ãæ°åã³ãããŠã€ã«ã¹ã®ã¯ã¯ãã³ã«ãããŠADEãæžå¿µãããããšã¯çŸç¶ã§ã¯ãšãŠãèãã«ãããšèšããŸãã
N Engl J Med. 2018;379:327-40
N Engl J Med. 2020;383:2603-2615
N Engl J Med. 2021;384:403-416
N Engl J Med. 2020;383:1544-1555
bioRxiv. A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates